Diffuse Large B-Cell Lymphoma Beyond the Nodes: A Case Series of Rare Extranodal Presentations in the Nasopharynx, Breast and Central Nervous System

Abstract

Background: Lymphomas may originate from nodal or extranodal sites, with an increasing proportion of patients presenting with extranodal non-Hodgkin Lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of NHL, seldom involves the nasopharynx, breast or central nervous system (CNS).

Objectives: In this study we described three rare primary extranodal presentations of DLBCL.

Methods: One case was nasopharyngeal DLBCL in a 13 years old boy who presented with recurrent nasal bleeding, obstruction, and discharge. Second case was breast DLBCL in a 72 years old female patient who had chief complaint of right breast lump for last 1 month without axillary lymphadenopathies. We had third case of DLBCL involving brain in a 50 years old male patient who had persistent headache and dizziness.

Case presentation: All the three cases had clinical suspicion of malignancy which was most common in that site.

Conclusion: Hence these cases emphasized the diagnostic importance of histopathology and immunohistochemistry in arriving at the correct diagnosis.