Diffuse Large B-Cell Lymphoma Beyond the Nodes: A Case Series of Rare Extranodal Presentations in the Nasopharynx, Breast and Central Nervous System

Background: Lymphomas may originate from nodal or extranodal sites, with an increasing proportion of patients presenting with extranodal non-Hodgkin Lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of NHL, seldom involves the nasopharynx, breast or central nervous system (CNS). Objectives: In this study we described three rare primary extranodal presentations of DLBCL. Methods: One case was nasopharyngeal DLBCL in a 13 years old boy who presented with recurrent nasal bleeding, obstruction, and discharge. Second case was breast DLBCL in a 72 years old female patient who had chief complaint of right breast lump for last 1 month without axillary lymphadenopathies. We had third case of DLBCL involving brain in a 50 years old male patient who had persistent headache and dizziness. Case presentation: All the three cases had clinical suspicion of malignancy which was most common in that site. Conclusion: Hence these cases emphasized the diagnostic importance of histopathology and immunohistochemistry in arriving at the correct diagnosis.

 Introduction

Lymphomas represent a diverse group of malignant neoplasms derived from lymphocytes, characterized by clonal proliferation of these cells or their precursors due to somatic mutations [1]. They are broadly divided into Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), which differ in morphology, immunophenotype, biology, and clinical presentation. NHL is further subclassified into B- and T-cell types, with precursor and mature B-cell categories recognized within the B-cell group. Among them, Diffuse Large B-cell Lymphoma (DLBCL) is the most frequently diagnosed NHL worldwide. Based on gene expression profiling (GEP), DLBCL can be categorized into germinal center B-cell (GCB)-like, activated B-cell (ABC)-like, and unclassifiable type 3 subgroups, each demonstrating distinct chromosomal alterations, signaling pathway activation, and prognostic differences [2]. Studies have shown that patients with the GCB subtype of DLBCL achieve higher complete response rates (~75-80%) with R-CHOP therapy compared to those with the ABC subtype (around 40-50%), reflecting the intrinsic molecular heterogeneity and prognostic differences between these subtypes [3, 4].

DLBCL is the most common primary B-cell neoplasm occurring in the head and neck region, with a predilection for the Waldeyer’s ring. Primary nasopharyngeal lymphoma is exceedingly rare, most often presenting as DLBCL or NK/T-cell lymphoma, with Epstein–Barr virus implicated in its pathogenesis [5].

It occurs more often in Asian populations and shows male predominance (55%) with a median age of 64 years. The disease typically presents in the sixth to eighth decades of life, although immunodeficiency may predispose to earlier onset [6].

Primary Breast Lymphomas (PBL) was first described in 1959 by Dobrotina [7]. It is uncommon entity which accounts for 0.1 - 0.15% of primary breast malignancies [8, 9]. Most primary breast lymphomas are of B-cell origin in which DLBCL is the most common diagnosis followed by MALT lymphoma, follicular lymphoma, Marginal Zone Lymphoma and Burkitt lymphoma [7, 10-12].

Primary central nervous system lymphoma (PCNSL) accounts for 3–4% of primary brain tumors and 4–6% of extranodal lymphomas, with a median diagnostic age of 65 years.

We are reporting three cases of primary extranodal DLBCL in rare sites. All patients were diagnosed as extranodal DLBCL variants (GCB, ABC or triple positive subtypes) via immunohistochemistry per the Hans algorithm.

<italic id="italic-1">Case 1<italic id="italic-2"/></italic>

A 13-year-old boy presented to the ENT clinic with recurrent bilateral epistaxis and purulent nasal discharge for one month, followed by nasal obstruction, breathing difficulty, and sneezing for four days. There was no history of fever, facial pain, weight loss, night sweats or trauma. Examination revealed a posterior choanal mass without lymphadenopathy or organomegaly (Table 1).

Case Age Gender Site Symptoms
1 13 M Nasopharynx Recurrent epistaxis
2 72 F Right Breast Breast lump
3 50 M Posterior fossa Brain Persistent headache

Routine investigations were normal. On the basis of clinical examination, the initial differentials included adenoidal hypertrophy, lymphoproliferative disorder, and rhabdomyosarcoma. CT scan demonstrated a well-defined soft-tissue lesion arising from the posterior nasopharyngeal wall, extending into both choanae and compressing the right eustachian tube (Figure 1), with associated middle-ear effusion.

while 18F-FDG PET-CT showed a metabolically active nasopharyngeal lesion with FDG-avid (SUVmax~13.8) lymph nodes above and below the diaphragm, consistent with stage III disease and helped to exclude benign adenoid enlargement. The mass was excised surgically and sent for histopathology. Histopathology revealed diffuse infiltration by sheets of atypical medium- to large-sized lymphoid cells (Figure 2) displaying irregular round nuclei displaying moderate pleomorphism, vesicular chromatin, central prominent nucleoli and scant cytoplasm.

Frequent atypical mitotic figures and large area of necrosis also seen (Figure 3).

On suspecting malignancy, Immunohistochemistry was performed (Table 2) which leads to the diagnosis of DLBCL (GCB subtype) (Figure 4-6) and effectively excluded rhabdomyosarcoma.

Case Site CD45 CD20 CD5 CD3 CD10 CD79a Bcl2 Bcl6 MUM1 P53 PD-L1 Ki-67
1 Nasopharynx Positive Negative Positive Negative Positive Positive Positive Positive negative Positive Positive 95%
2 Breast Positive Positive Negative Negative Negative Positive Positive Negative Positive *NA *NA 80-85%
3 Posterior Fossa Brain Positive Positive Negative Negative Positive Positive Positive Positive Positive *NA *NA 70%

*NA, Not applied

Due to CD20 negativity, standard anti-CD20 therapy alone was not feasible, and the patient was referred to a higher center for further management. The patient was initiated on a combination CHOP-based chemotherapy regimen including rituximab, hydrocortisone, cyclophosphamide, doxorubicin, vincristine and Mesna, along with supportive care to prevent toxicity and close monitoring of hematological and organ function. Unfortunately, the patient was lost to follow up, and the subsequent treatment response could not be assessed.

<italic id="italic-391ea8df5aaba3b50f9e9bc79f801c0e">Case 2<italic id="italic-4a437be8706a04eaed3ce0efaef156f3"/></italic>

A 72 years old female patient presented to Endocrine surgery OPD with a 1-month history of a right breast lump. On examination 5 x 3 cm swelling was seen in lower inner quadrant of right breast. It was firm, non tender with adjacent and overlying skin normal. Left breast was also normal. No axillary lymph nodes were palpable. On the basis of clinical examination, a suspicion of malignancy was made. Fine needle aspiration cytology was advised and it was suggestive of positive for malignancy, (Figure 7) and for further typing biopsy was advised We received Trucut biopsy of breast lump comprising of multiple grey white soft tissue cores collectively measuring 1.0 x 1.0 x 0.5 cm.

Microscopic features revealed fibro-collagenous tissue cores infiltrated by tumor cells which were predominantly scattered singly. These tumor cells were medium to large in size, having round to oval nuclei, irregular nuclear membrane, conspicuous nucleoli, vesicular chromatin and moderate amount of cytoplasm. Fair number of mitotic figures were noted (Figure 8).

On the basis of histopathological features, differentials considered were metaplastic carcinoma and lymphoma. Immunohistochemistry was positive for CD45 (Figure 9), CD 19, CD20 (Figure 10), MUM-1 (Figure 11), BCL2 (Figure 12) and negative for ER, PR, Her2neu, P63, CK5/6, vimentin, CD3, CD5, CD10 and BCL6.

While Ki-67 proliferative index was 80-85%. On the basis of histomorphology and IHC final diagnosis of DLBCL (Non Germinal Centre subtype) was made and effectively excluded metaplastic carcinoma. The patient was found to be non-metastatic on 18F-FDG PET-CT and a diagnosis of primary breast DLBCL, Stage IE was made. The case was discussed in a multi-disciplinary team meeting and the patient was started on R-CHOP regimen with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone. Post 6 cycles of chemotherapy, the patient was found to have metabolic complete response on a repeat PET-CT and has been planned for Radiotherapy to the right breast. The patient has been advised strict follow up.

<italic id="italic-20a0719676f77c9508f761bd143e17b6">Case 3<italic id="italic-e39b80fc77711ca6bf8c4c2e5b135d81"/></italic>

A 50-year-old male presented with six months of persistent headaches, dizziness, and fatigue, without neurological deficits or systemic illness. MRI brain revealed relatively well defined homogenously enhancing posterior fossa mass lesions suggestive of metastasis, high grade glioma or ependymoma. Surgical excision yielded firm, pearly-white tissue. The diagnosis of high- grade glioma was made on squash smear. Tumor tissue was further sent for histopathology. Microscopy showed brain parenchyma infiltrated by sheets of medium-to-large neoplastic lymphoid cells. No rosettes or fibrillary material was seen. The tumor cells were displaying hyperchromatic nuclei, inconspicuous nucleoli and scant cytoplasm. Frequent mitotic figures also seen (Figure 13).

On the basis of histopathology, possibility of lymphoma was considered. Immunohistochemistry confirmed diffuse large B-cell lymphoma (DLBCL) (Table 2), triple positive for CD10, BCL-6, and MUM-1, with a Ki-67 index of 70% (Figure 14, 15).

The patient was discharged for adjuvant chemotherapy and advised to undergo six cycles of combination chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP regimen). He has completed one cycle of chemotherapy and is showing favourable clinical improvement. Supportive measures and close monitoring for hematological, hepatic and neurological toxicities was provided throughout the course of treatment. The patient continues remain under regular follow up for assessment of therapeutic response and completion of the remaining chemotherapy cycles.

Discussion <italic id="italic-57c8fbda17868a1e92d218e211b02836">Primary DLBCL of nasopharynx<italic id="italic-29f2d37068352f6db77e7addbef43f22"/></italic>

Diffuse large B-cell lymphoma (DLBCL) shows primary extranodal involvement in about 40% of cases, with a higher incidence in India (34–60%). Primary nasal cavity disease is rare (0.2–2%), though extranodal lymphomas of the tonsils, pharynx, and paranasal sinuses are usually B-cell derived. In India nasopharyngeal DLBCL is rare and may be influenced by region-specific factors such as Epstein-Barr virus (EBV) infection and underlying immunodeficiency, which can predispose to aggressive extranodal disease. A study by Rathaur et al. (1999) found that 70% of nasopharyngeal carcinomas in India were EBV positive with Type A EBV detected in 71.4% and type B in 25% of cases [13]. These factors contribute to the distinct biological behavior of nasopharyngeal lymphomas compared with conventional nodal DLBCL. Recognition of these influences is important for accurate diagnosis and appropriate therapeutic planning.

In our case patient had nasal bleeding, discharge, and obstruction without B symptoms. Because it mimics granulomatous or neoplastic conditions, timely recognition requires a high index of suspicion [14-16) Morphologically, it appeared as centroblastic. IHC typically shows positivity for CD45, B-cell markers (CD79a, CD19) and positivity for BCL2, BCL6 and CD10 with high Ki-67 index of 95%. This case is unique in view of its immunohistochemical profile, characterized by loss of CD 20 expression, aberrant CD5 positivity, P53 positivity and PD-L1 (5-10%) positivity, a combination that is rarely reported and complicates rituximab-based therapy.

CD5 expression is detected in approximately 5 to 10% of DLBCL cases and is often associated with aggressive clinical behavior [17]. Loss of CD20 expression is uncommon, observed in 1-2% of de novo DLBCL [18]. Overexpression of p53 occurs in about 20-40% of DLBCL and has been linked to poor prognosis [19]. PD-L1 expression in tumor cells is reported in approximately 5-10% of DLBCL cases, contributing to immune evasion mechanism [20]. So, early classification is crucial for managing DLBCL, with nasal cases treated similarly to other sites. Prognosis depends on stage and tumor burden, though sinonasal lymphomas often behave aggressively with relapse risk [21, 22]. A cohort study reported 56% overall survival and 50% five-year progression-free survival, with 22% recurrence in primary sinonasal DLBCL. Continuous surveillance and long-term follow- up are essential.

<italic id="italic-4ecaa005aeee205de1afb3304b05c4aa">Primary DLBCL of Breast<italic id="italic-05d97e57f448732e26e10bb717198205"/></italic>

Primary breast Lymphoma is rare entity. It typically a B cell origin which accounts for approximately 50% of all PBL [6, 23]. In general, patients give history of short duration with rapid increase in size. The clinical presentation is more or less similar to other breast carcinoma but single, painless palpable breast lump is the most common finding, however retraction of nipple and skin as well as nipple discharge are rarely seen. The usual B symptoms like fever, weight loss and night sweats which are seen in primary lymphoma are generally not seen in PBL [24, 25]. Some researchers mentioned that most frequent quadrant involved in decreasing order are upper outer, upper inner, lower outer and nipple/areolar region [25-27]. In the literature few authors described that association between lymphoma and pregnancy which suggest that hormonal disturbances play an important role in the pathogenesis of breast lymphoma [6]. PBL is mostly occur in females but few cases were reported in males also. Mean age at presentation is 60-65 years although it can also occur at younger age. Sakhri S et al [4] reported in the case series of PBL, one of their patients who is aged 17 years and associated with an aggressive prognosis.

Imaging features of PBL is nonspecific and may resemble with other breast malignancies. But very helpful in defining margin and vascularity of the lesion. PET CT play a crucial role in the evaluation of response to therapy and it is also valuable in the staging, metastasis and follow up [6, 28].

In DLBCL, Non- GCB type is commoner than GCB type. Wiseman and Liao [29] proposed the following three diagnostic criteria for PBL: (1) the mammary gland tissue and tumor tissue have a close relationship; (2) an appropriate histopathological evaluation has been performed; and (3) no malignant lymphoma is found at sites other than the mammary gland at the first visit, although ipsilateral axillary lymph node metastasis may be present. Our case met these criteria and was diagnosed as malignant lymphoma of the mammary gland. The histomophological features and IHC markers of our case are similar as described by Sakhri S et al [6], James ER et al [30] and Yoneyyama K et al [25].

James ER et al. [30] noted that Primary breast Diffuse Large B-cell Lymphoma (PB-DLBCL) necessitates systemic therapies, including chemotherapy, radiotherapy, and immunotherapy. The standard treatment regimen typically comprises six cycles of R-CHOP, which includes rituximab a monoclonal antibody targeting CD20 that depletes CD20-positive B cells along with a combination of four chemotherapeutic agents: cyclophosphamide, doxorubicin, vincristine, and prednisone. Sakhri S et al. [6] emphasized that treatment guidelines are contingent upon the histological subtype and clinical stage of the disease. It is well established that the CHOP regimen remains the standard therapeutic approach for primary diffuse large B-cell lymphoma (DLBCL) of the breast, with the recent incorporation of targeted therapies. Studies have shown that patients treated with R-CHOP achieve a 5-year overall survival rate ranging from 70% to 80%, reflecting significant improvement compared to historical outcomes with CHOP alone [31]. Polutazumab vedotin, an antibody-drug conjugate targeting CD79b on B cell, has emerged as a promising therapy for relapsed or refractory DLBCL. Although experience in primary breast DLBCL is limited [32].

<italic id="italic-508f19ede59576a9d78b9638040f2b7c">Primary DLBCL of Posterior fossa of brain<italic id="italic-80539e08f7e8887db1d5a9ed989d5585"/></italic>

Accounting for only 1–2% of non-Hodgkin lymphomas, primary CNS lymphoma is an infrequent but aggressive neoplasm. Diffuse Large B-cell lymphoma (DLBCL) constitutes the overwhelming majority of cases, with an incidence of approximately 84.6% [33, 34] Involvement of the central nervous system (CNS) is relatively rare in diffuse large B-cell lymphoma (DLBCL) when compared with other aggressive lymphomas, such as Burkitt’s lymphoma and lymphoblastic lymphoma [35] Symptomatology largely depends on the region affected and may include cranial neuropathies, prolonged headache, behavioral disturbances, changes in consciousness, and seizure activity [36, 37]. Radiological findings in CNS Lymphoma can vary significantly. Approximately 25% of patients may display atypical radiologic findings [38], which can complicate diagnosis of lymphoma, mimicking other conditions such as glioblastoma [39] or even neuroinflammatory diseases [40]. CNS relapses in DLBCL are rare but have devastating complications, occurring in 2–5 percent of overall cases [41]. In double expression lymphoma, the incidence of CNS relapse reaches 9.7 percent at 2 years [42].

The International Prognostic Index (IPI) is widely used to stratify risk and predict outcome in DLBCL, incorporating five parameters: age>60 years, performance status≥2, elevated serum lactate dehydrogenase (LDH), advanced stage (III-IV) and involvement of more than one extranodal site. Each factor scores one point, and the total score categorizes patients into low (0-1), low-intermediate (2), high-intermediate (3), and high risk (4-5) groups, correlating with overall survival [43].

The concurrent positivity for BCL6, CD10 and MUM- 1 observed in case no. 3, contrasts with the conventional immune-profiles reported in most DLBCL, highlighting its diagnostic complexity and rarity. These triple positive DLBCL are considered as heterogenous group and are enriched in IRF4 rearrangements. These rearrangements may drive B cell receptor signaling activation and contribute to aggressive disease biology. Such molecular features highlight the potential utility of targeted therapies, including Bruton’s tyrosine kinase (BTK inhibitors), particularly in relapsed or refractory cases, emphasizing the importance of integrating molecular profiling with conventional IHC to guide personalized treatment strategies.

In conclusion, this case series highlights the diagnostic complexity and clinicopathological diversity of DLBCL involving rare primary extranodal sites such as nasopharynx, breast and brain. Unusual immunophenotypic profiles underscores the biological heterogeneity of these cases. However, the small sample size and loss to follow up limit the generalizability and long-term prognostic interpretation of our findings. Despite these constraints, our observations add to the limited existing literature and emphasize the need for larger, multicentric studies with prolonged follow-up to better understand the behavior and therapeutic response of DLBCL at uncommon primary extranodal sites.

Declarations

Clinical trial registration

Not applicable

Conflicts of interest

Authors declare that they have no conflicts of interest.

Availability of data and material

The data sets used and/or analyzed during the current study are available from the corresponding authors per reasonable request.

Code availability

The custom code was used.

Originality Declaration for Figures

All figures included in this manuscript are original and have been created by the authors specifically for the purposes of this study. No previously published or copyrighted images have been used. The authors confirm that all graphical elements, illustrations, and visual materials were generated from the data obtained in the course of this research or designed uniquely for this manuscript.

Ethics approval

As per the norms of our university, ethical clearance is not required for publications based on case series, provided that patient identity is protected and informed consent has been obtained.

Consent to participate

Not applicable

Consent for publication

Informed/written consent was taken from all the three cases in the study for publication of their case.

Originality Declaration for Figures

All figures included in this manuscript are original and have been created by the authors specifically for the purposes of this study. No previously published or copyrighted images have been used. The authors confirm that all graphical elements, illustrations, and visual materials were generated from the data obtained in the course of this research or designed uniquely for this manuscript.

Acknowledgments

We extend our heartfelt gratitude to all the patients who generously contributed to this study. We are particularly thankful to technical and nursing staff of Department of Pathology, ENT, Endocrine Surgery and Neurosurgery, UPUMS, Saifai, Etawah.

Declaration on generative AI and AI-assisted technologies in the writing process

Not applicable.

References 1 03 67 5 2022 10.4103/crst.crst_204_21 Nair SC Gogia A Arora S Kumar L Sharma A Biswas A Gupta R Mallick S Cancer Research, Statistics, and Treatment Clinicopathologic features and outcomes of diffuse large B-cell lymphoma with extranodal involvement: A retrospective analysis 4 572-575 26 2022 10.4103/jomfp.jomfp_410_21 Abeles EB Umrau K Gray ML Boahene KD Journal of oral and maxillofacial pathology: JOMFP Primary diffuse large B-cell lymphoma of the nasal bone and palate: An unusual clinical presentation 15 6 09 851-862 198 2003 10.1084/jem.20031074 Rosenwald A Wright G Leroy K Yu X Gaulard P Gascoyne RD Chan WC et al The Journal of Experimental Medicine Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma 8 08 922-926 21 2015 10.1038/nm.3884 Wilson WH Young RM Schmitz R Yang Y Pittaluga S Wright G Lih CJ et al Nature Medicine Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma 10.31557/APJCC.2022.7.2.405-408 Cruz MV Asian Pacific Journal of Cancer Care Case Series of Rare Primary Intranasal Diffuse Large B-cell Lymphoma among Filipinos 8 08 e28085 14 2022 10.7759/cureus.28085 Patel V Tacy CJ Creamean T Sibia A Patel J Cureus Atypical Location of Diffuse Large B-cell Lymphoma in the Nasal Septum 28 1 06 290 17 2023 10.1186/s13256-023-03998-8 Sakhri S Aloui M Bouhani M Bouaziz H Kamoun S Slimene M Ben Dhieb T Journal of Medical Case Reports Primary breast lymphoma: a case series and review of the literature 28 3 07 205-207 7 2025 10.18231/j.achr.2022.046 A. Ansari S Agrawal T Bhamra S IP Archives of Cytology and Histopathology Research Diagnostic surprise on IHC: A rare case of intramuscular DLBCL in thigh region mimicking sarcoma Gailard F Gaillard F. Breast lymphoma|Radiology Reference Article|Radiopaedia.org [Internet]. Radiopaedia. [cité 30 mars 2020]. Disponible sur: https:// radio paedia. org/ artic les/ breast- lymphoma 6 06 599-605 13 2000 10.1038/modpathol.3880103 Aguilera NS Tavassoli FA Chu WS Abbondanzo SL Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc T-cell lymphoma presenting in the breast: a histologic, immunophenotypic and molecular genetic study of four cases 1 01 91-93 149 2014 10.1001/jamasurg.2013.2283 Radkani P Joshi D Paramo JC Mesko TW JAMA surgery Primary breast lymphoma: 30 years of experience with diagnosis and treatment at a single medical center 1 01 33-36 30 2000 10.1093/jjco/hyd008 Suzuki Y Tokuda Y Okumura A Saito Y Ohta M Kubota M Makuuchi H et al Japanese Journal of Clinical Oncology Three cases of malignant lymphoma of the breast 2-4 80-90 36 1999 Rathaur RG Chitale AR Banerjee K Indian Journal of Cancer Epstein-Barr virus in nasopharyngeal carcinoma in Indian patients 2 135-141 55 2011 10.1159/000320907 Gupta N Kaur J Srinivasan R Das A Mohindra S Rajwanshi A Nijhawan R Acta Cytologica Fine needle aspiration cytology in lesions of the nose, nasal cavity and paranasal sinuses 2 04 160-171 40 2022 10.1002/hon.2968 Eriksen PRG Clasen-Linde E Nully Brown P Haunstrup L Christoffersen M Asdahl P Thomsen TM et al Hematological Oncology Sinonasal B-cell lymphomas: A nationwide cohort study, with an emphasis on the prognosis and the recurrence pattern of primary diffuse large B-cell lymphoma 12 12 1797-1807 25 2011 10.1038/leu.2011.169 Deckert M Engert A Brück W Ferreri AJM Finke J Illerhaus G Klapper W et al Leukemia Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma 7 07 1601-1607 22 2011 10.1093/annonc/mdq627 Miyazaki K Yamaguchi M Suzuki R Kobayashi Y Maeshima AM Niitsu N Ennishi D et al Annals of Oncology: Official Journal of the European Society for Medical Oncology CD5-positive diffuse large B-cell lymphoma: a retrospective study in 337 patients treated by chemotherapy with or without rituximab 12 12 835-843 59 2009 10.1111/j.1440-1827.2009.02466.x Shimoyama Y Asano N Kojima M Morishima S Yamamoto K Oyama T Kinoshita T Nakamura S Pathology International Age-related EBV-associated B-cell lymphoproliferative disorders: diagnostic approach to a newly recognized clinicopathological entity 19 16 04 3668-3683 119 2012 10.1182/blood-2011-11-366062 Xu-Monette ZY Medeiros LJ Li Y Orlowski RZ Andreeff M Bueso-Ramos CE Greiner TC McDonnell TJ Young KH Blood Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies 05 19 11 2193-2201 126 2015 10.1182/blood-2015-02-629600 Kiyasu J Miyoshi H Hirata A Arakawa F Ichikawa A Niino D Sugita Y et al Blood Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma 817043 12 2022 10.3389/fonc.2022.817043 Tang D Chen Y Shi Y Tao H Tao S Zhang Q Ding B et al Frontiers in Oncology Epidemiologic Characteristics, Prognostic Factors, and Treatment Outcomes in Primary Central Nervous System Lymphoma: A SEER-Based Study 8 08 451-457 15 2015 10.1016/j.clml.2015.02.026 Ghose A Elias HK Guha G Yellu M Kundu R Latif T Clinical Lymphoma, Myeloma & Leukemia Influence of Rituximab on Central Nervous System Relapse in Diffuse Large B-Cell Lymphoma and Role of Prophylaxis--A Systematic Review of Prospective Studies 1 02 27-33 7 2011 10.5114/aoms.2011.20600 Joks M Myśliwiec K Lewandowski K Archives of medical science: AMS Primary breast lymphoma - a review of the literature and report of three cases 5 05 181-185 12 2021 10.14740/jmc3660 Chen M Zhou J Qu X Journal of Medical Cases Primary Breast Diffuse Large B-Cell Lymphoma in a 42-Year-Old Female: A Case Report and Review of Literature 1 01 55-61 16 2021 10.1016/j.radcr.2020.10.039 Yoneyama K Nakagawa M Hara A Radiology Case Reports Primary lymphoma of the breast: A case report and review of the literature 20 05 52 6 2008 10.1186/1477-7819-6-52 Garg NK Bagul NB Rubin G Shah EF World Journal of Surgical Oncology Primary lymphoma of the breast involving both axillae with bilateral breast carcinoma 159-163 7 2013 10.4137/CMO.S12044 Inic Z Inic M Zegarac M Inic I Pupic G Clinical Medicine Insights. Oncology Three Cases of Combined Therapy in Primary Breast Lymphoma (PBL) with Successful Outcomes 4 08 815-821 13 2018 10.1016/j.radcr.2018.04.009 Wadhwa A Senebouttarath K Radiology Case Reports Primary lymphoma of the breast: A case series 6 06 1705-1712 29 1972 10.1002/1097-0142(197206)29:6<1705::aid-cncr2820290640>3.0.co;2-i Wiseman C Liao KT Cancer Primary lymphoma of the breast 06 127-143 32 2022 10.1016/j.jpra.2022.01.004 James ER Miranda RN Turner SD JPRAS open Primary Lymphomas of the Breast: A Review 2 02 233-241 19 2008 10.1093/annonc/mdm471 Ryan G Martinelli G Kuper-Hommel M Tsang R Pruneri G Yuen K Roos D et al Annals of Oncology: Official Journal of the European Society for Medical Oncology Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group 01 9 09 2802-2809 109 2024 10.3324/haematol.2022.282362 Ghione P Salles G Haematologica Spotlight on polatuzumab vedotin: new standards for diffuse large B-cell lymphoma? 2 06 61-70 27 2009 10.1002/hon.881 Ferreri AJM Assanelli A Crocchiolo R Ciceri F Hematological Oncology Central nervous system dissemination in immunocompetent patients with aggressive lymphomas: incidence, risk factors and therapeutic options 2 08 128-135 84 2006 10.1532/IJH97.06091 Tomita N Kodama F Kanamori H Motomura S Ishigatsubo Y International Journal of Hematology Secondary central nervous system lymphoma 5 05 1319-1326 176 2001 10.2214/ajr.176.5.1761319 Erdag N Bhorade RM Alberico RA Yousuf N Patel MR AJR. American journal of roentgenology Primary lymphoma of the central nervous system: typical and atypical CT and MR imaging appearances 6 984-992 32 2011 10.3174/ajnr.A2171 Haldorsen IS Espeland A Larsson EM AJNR. American journal of neuroradiology Central nervous system lymphoma: characteristic findings on traditional and advanced imaging 1 01 29-35 43 2001 10.1007/s002340000480 Thurnher MM Rieger A Kleibl-Popov C Settinek U Henk C Haberler C Schindler E Neuroradiology Primary central nervous system lymphoma in AIDS: a wider spectrum of CT and MRI findings 887249 9 2022 10.3389/fsurg.2022.887249 Talybov R Beylerli O Mochalov V Prokopenko A Ilyasova T Trofimova T Sufianov A Guang Y Frontiers in Surgery Multiparametric MR Imaging Features of Primary CNS Lymphomas 2 10 185-194 187 2019 10.1111/bjh.16070 Eyre TA Kirkwood AA Wolf J Hildyard C Mercer C Plaschkes H Griffith J et al British Journal of Haematology Stand-alone intrathecal central nervous system (CNS) prophylaxis provide unclear benefit in reducing CNS relapse risk in elderly DLBCL patients treated with R-CHOP and is associated increased infection-related toxicity 05 18 05 2182-2188 127 2016 10.1182/blood-2015-10-676700 Savage KJ Slack GW Mottok A Sehn LH Villa D Kansara R Kridel R et al Blood Impact of dual expression of MYC and BCL2 by immunohistochemistry on the risk of CNS relapse in DLBCL 4 04 e15150 9 2023 10.1016/j.heliyon.2023.e15150 Feng A Li L Huang T Li S He N Huang L Zeng M Lyu J Heliyon Differentiating glioblastoma from primary central nervous system lymphoma of atypical manifestation using multiparametric magnetic resonance imaging: A comparative study 15 11 577970 372 2022 10.1016/j.jneuroim.2022.577970 Raza SA Raza M Dai M Husan A Cotelingam J AlHussein H Journal of Neuroimmunology Lymphomas mimicking neuroinflammatory diseases - A diagnostic conundrum worth revisiting 01 5 03 1857-1861 109 2007 10.1182/blood-2006-08-038257 Sehn LH Berry B Chhanabhai M Fitzgerald C Gill K Hoskins P Klasa R et al Blood The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP