Meta Analysis of the Outcomes in Doing Active Surveillance and Surgical Approach for Micropapillary Thyroid Carcinoma

Introduction: Micropapillary thyroid carcinoma was emerging as an epidemic disease worldwide. Due to its unaggressiveness and slow-growing feature, either doing active surveillance or surgical approach were controversial for its management. This meta analysis aimed to determine the pooled proportion outcomes of doing active surveillance and surgery in micropapillary thyroid carcinoma. Methods: This meta analysis of the results in doing active surveillance and surgical approach for micropapillary thyroid carcinoma, designed followed the PRISMA guidelines. Relevant studies were obtained from Medline (2008-2018) and SCOPUS (2008-2018) in the last 20 years. The scope of data collection is about the author, year of study, and number of subjects. The parameter of this study was pooled proportion. Data were analyzed by MedCalc 13.5 and the significance limit was 0.05. Results: The pooled proportion of cases of surgery conversion, increasing tumor size more than 3 cm, and the presence of lymph node metastases during active surveillance of micropapillary thyroid carcinoma were 14.996; 6.125%; and 4.988%, respectively. The pooled proportion of cases of recurrence and lymph node metastases after surgery of micropapillary thyroid carcinoma were 3.539% and 14.071%, respectively. Discussion: In this study, it was showed that result was favorable in doing active surveillance. The rate of lymph node metastases were comparable in non and interventional group. However, this approach should be considered cases by cases. Many individual factors like age, gender, and comorbidities should be considered. Conclusion: Active surveillance was a safe and considered approach for micropapillary thyroid carcinoma. However, some risk factor should be considered for surveillance exclusion.

 <bold id="bold-4be0f965aa65d2d9d99d2bd58fb2ea56">Introduction</bold>

Papillary carcinoma accounted approximately 85% of thyroid tumors, in which surgery is the standard of care [1]. In several cases where, papillary thyroid was dicovered as microcarcinoma, either doing surgical or conservative approach was still controversial until now [2]. Papillary microcarcinomas mostly was less aggressive, in which active surveillance was preferred. Recently, some authors classified there were low- risk and high risk disease. Thus, immediate surgical management was being reconsidered and debated [3]. Active surveillance has emerged to address the concern for over-treatment of low-risk papillary microcarcinoma [4]. The term of active surveillance can be defined as a care plan that observe the patient’s condition regularly without any treatment unless the condition is getting worse [5]. Ito and team were the first team to propose the modality of active surveillance for micropapillary thyroid carcinoma in Japan. Supported by their study from 1993 to 2010, they proved that active surveillance was comparable to that of surgery in 22 year prospective follow up [6]. After that, most studies from Japan highlighted the modalities of active surveillance rather than surgical approach for micropapilary thyroid carcinoma [7]. Kwon et al. in single-center study of South Korea also showed that it was worth of doing active surveillance due to the stability of tumor over 3.8 years [8]. Then, in 2017, Tuttle from United States proved that the growth rates of papillary thyroid microcarcinomas were lower than 1.5 cm, therefore, recommended the conservative modalities [9]. Recently, the ATA introduced guidelines for active surveillance management as an alternative to immediate thyroid surgery for patients with very low-risk tumors [1]. Despite these results, active surveillance has yet to become widely accepted. Progression on its clinical stage remains an absolute switch to surgical intervention [10-28]. Therefore, this meta analysis aim to determine results in doing active surveillance and surgical approach for micropapillary thyroid carcinoma.

 <bold id="bold-7c6f4a3a3a50ef41791432b716b90050">Materials and Methods</bold>

This study presented a meta-analysis of the results in doing active surveillance and surgical approach for micropapillary thyroid carcinoma. The study design followed the PRISMA guidelines for meta-analysis, based on the Cochrane Handbook for Systematic Review of Interventions guidelines.

A comprehensive literature search were conducted by the authors on December 30th, 2018 to March 1st 2019. Relevant studies were obtained from Medline (2008-2018) and SCOPUS (2008-2018) in the last 20 years. The eligible studies were searched with the keywords based on the meta analysis title. Duplicate journals were managed using EndNote. The title and abstract of the studies were reviewed. The full texts were analyzed for inclusion if they contain original data from the group, clinical trials, and observational studies. Only English language journals and full text are included in this study.

The scope of data collection is about the author, year of study, and number of subjects. The parameter of this study was pooled proportion. Data were analyzed by MedCalc 13.5 and the significance limit was 0.05. For those studies with the data of survival proportion, dichotomous analysis were perfomed. Dichotomous data were presented as odds ratios (ORs) with 95% confidence intervals (CI) (Figure 1).

<bold id="bold-b827213fb9256f67fd8d7199719c9a5a">Results</bold>

There were respectively 11 studies that included in this meta analysis to determine the recurrence and lymph node metastasis rate in micropapillary thyroid managed by surgery (Table 1).

Study Year Country N Modalities Duration(year) Recurrence(n) Lymph nodemetastasis (n) Overall survival (%)
Besic [12] 2007 Slovenia 228 Surgery 31 7    
Hay [13] 2008 USA 892 Surgery 40 72    
Zuniga [14] 2009 Colombia 266 Surgery   45 122  
Ross [15] 2009 USA 2572 Surgery   30    
Ito [16] 2010 Japan 1055 Surgery 15 32 146  
Yu [17] 2011 USA 18445 Surgery 19 91 2294 90.7
Gershinsky [18] 2012 Israel 293 Surgery 7.2 34 54  
Karatzas [19] 2013 Greece 311 Surgery   12 30  
Nixon [20] 2013 USA 1129 Surgery 5.8 1    
Hwangbo [21] 2016 Korea 3282 Surgery 2 55 121  
Li [22] 2019 China 161 Surgery   3 10  

The pooled proportion of recurrence after surgery of micropapillary thyroid carcinoma was 3.539% (95% CI 1.898-5.665; I2 97.8 %; Figure 2).

The pooled proportion of lymph node metastasis cases after surgery in micropapillary thyroid carcinoma was 14.071% (95% CI 8.449-20.843; I2 98.83%; Figure 3).

There were 12 studies that included in this meta analysis to determine the rate of delayed surgeries, cases of increasing tumor size more than 3 cm, lymph node metastasis, and symptomatic cases in micropapillary thyroid managed by active surveillance (Table 2).

Study Year Country N Observation Duration(years) Convert to surgery (n) Increase tumorsize > 3 mm (n) Lymph nodemetastases (n) Symptomatic(n)
Ito [16] 2010 Japan 340 Periodic USG 75 mo 109 31 7 8
Sugitani [23] 2010 Japan 244 Periodic 5   22 3  
        physical          
        examination          
        and USG          
Smulever [24] 2015 Argentina 34 Periodic USG 4 5 6    
Fukuoka [25] 2016 Japan 480 Periodic USG 6.8   29    
Oda [26] 2016 Japan 1179 Periodic USG 0.9 94 27 6  
Leboulleux [27] 2016 France 1235 Periodic USG 5   129 136 136
Kwon [8] 2017 Korea 192 Periodic 2.5 24 23 8  
        physical          
        examination          
        and USG          
Tuttle [9] 2017 USA 291 Periodic USG 2.1   11    
Sanabria [29] 2018 Colombia 57 Periodic USG 1.4 5 2    
Kim [30] 2018 Korea 126 Periodic USG 2.2 18 7 1  
Oh [31] 2018 Korea 370 Periodic 2.7 58 139 108  
        physical          
        examination          
        and USG          
Sakai [32] 2019 Japan 61 Periodic USG 2   36    

The pooled proportion of the symptomatic cases micropapillary thyroid carcinoma managed by active surveillance was 6.125% (95% CI 0.538-17.312; I2 97.12%; Figure 4).

The pooled proportion of the lymph node metastases cases in micropapillary thyroid carcinoma managed by active surveillance was 4.988% (95% CI 0.792-12.499; I2 98.4%; Figure 5).

The pooled proportion of cases of increase tumor size > 3 mm during active surveillance of micropapillary thyroid carcinoma was 12.212% (95% CI 6.769-18.891; I2 97.29%; Figure 6).

The pooled proportion of number of delayed surgeries during active surveillance of micropapillary thyroid carcinoma was 14.996% (95% CI 11.589-14.371; I2 94.53%; Figure 7).

<bold id="bold-a2e0f06ba7c235c1f0f5c70cc4e40402">Discussion</bold>

Micropapillary thyroid carcinoma has a less aggressive behavior and mostly presence without any symptoms [3]. Recent studies have shown more than 400% increase in micropapillary thyroid carcinoma prevalence along with the improvement of imaging technologies [33]. High-risk micropapillary thyroid carcinoma was defined as a microcarcinoma having one or more lymph node or distant metastasis, high- grade cytology, extra-thyroid extension or significant growth during a previous observation. Low-risk micropapillary thyroid carcinoma was defined a microcarcinoma having none of the afore-mentioned features [34].

Not all clinicians accepted the act of active surveillance for micropapillary thyroid carcinoma, with many aspect of considerations. Small papillary cancer can indeed metastasize or spread to other parts of the body. On the other hand, there is a common belief that thyroid cancer is relatively benign, because of the slow growth. Some studies showed that many considerations should be taken in applying active surveillance for micropapillary thyroid cancer [35]. Age, race, gender can significantly affect survival. Among these 3 factors, age of the subject was the most factor to be considered [36]. A recent report from the SEER program showed that the death rate from thyroid cancer was 2.7 of 100,000 in patients older than 65 years, while it is only 0.1 of 100,000 in patients younger than 65 years, a greater than 25-fold difference [37]. This phenomenon is reflected in several staging systems,including AJCC/pTNM and AMES staging systems. In this meta analysis, it was showed that the rate of cases that converted to surgeries while doing active surveillance was 14.996%, which was still an acceptable rate. The duration of follow up in active surveillance was ranging from 1 to 24 years [35]. The pooled proportion of cases with increasing tumor size more than 3 cm was 12.2%, which showed that no doubt the number of delayed surgeries was about similar. In this study, the pooled proportion cases of lymph node metastases were higher in intervention than active surveillance group, while this could be due to the cases chosen for intervention majority with N1 before. However, this number still indicated that active surveillance was promising to be done for micropapillary thyroid carcinoma.

This study supported the active surveillance approach for micropapillary thyroid cancer with low pooled proportion of numbers of delayed surgeries and lymph node metastases. This approach in the other hand should be preferred also due to its cost-effectivity. However, this approach should be considered cases by cases. Few studies were on going to carry out the exclusion criteria for active surveillance candidate. The upcoming study based in Canada (NCT03271892) was on going in patients with previously untreated papillary thyroid carcinoma with a tumor size less thant 2 cm, no lymph node involvement, and metastasis. The estimated completion date of the study is May 2026. Another study in Los Angeles (NCT02609685) also on going, was recruiting patients with papillary thyroid carcinoma, with tumor size less than 1.5 cm and estimated to be completed in December 2030. In conclusion, active surveillance was a safe and considered approach for micropapillary thyroid carcinoma.

However, the presence of some risk factors should be considered for surveillance exclusion.

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