Evaluation of respiratory exposure to 4,4-methylene diphenyl diisocyanate (MDI) vapors in foam injection workers in a household appliance manufacturing company: An Occupational Carcinogen
DOI:
https://doi.org/10.31557/apjec.2019.2.1.23-27Keywords:
MDI, Respiratory Exposure, Respiratory Capacity, Inject Foam Workers, Occupational CarcinogenAbstract
Background: Appliance manufacturing boom is very high hand customers always have a great deal of attention to products that have low energy consumption, therefore the use of isocyanates MDI as a thermal insulation in the body of the refrigerator and is also widely used as a binder in the production of washing machines. MDI isocyanate study the effects on the respiratory capacity of formers injection was done foam material in a household appliance company
Method: this case control study in 1395 and a household appliance manufacturing company in the province of Qazvin 20 personnel working injected foam material is exposed to isocyanates ,for example administrative personnel and 20 served as controls using medical records these values breathing capacity FVC , FEV1 , FEV1/FVC in both 1390 and 1394 extracted using SPSS software and paired T-TEST data were analyzed.
Results: Measuring the concentration of isocyanate in 90 blocks in the cabin and tap lid above the limit, which was due to the failure of the ventilation system, in 94 years due to the good performance of the ventilation system in the isocyanate concentration was at the limit. According to their experiences foam material is injected every three indexes FVC, FEV1, FEV1/FVC had significant losses, FEV1 and FVC decline among which were a significant level. (p=0.036, p= 0.008) the control samples also non- significant decline in the indicators that this can be attributed to aging.
Conclusion: It is known that exposure to isocyanate materials decreased respiratory capacity is personnel, to postpone it to the desired function ventilation system. it would be desirable to postpone the operation of the ventilation system and non-isocyanate leak on the ground, work, be a lot of attention. even with the improvement of the job must be conservative’s injection foam material is exposed to isocyanates be included in the list of hard and hazardous jobs.
Keywords: MDI, respiratory exposure, respiratory capacity, workers inject foam material.
References
The Association The Industries of Household Appliances of Iran. 2011:271.
KHATAMI FIROUZABADI SMA, SHAFIEI NIKABADI M, TEBYANIAN H, SHOJA N. ASSESSING THE EFFICIENCY OF HOSPITALS IN SEMNAN PROVINCE USING DATA ENVELOPMENT ANALYSIS WITH INPUT NATURE. KNOWLEDGE AND HEALTH. 2018;12(4 #G00186):-.
Golbabaie F, Eskandari D, Rezazade Azari M, Jahangiri M, Rahimi M, Shahtaheri J. Health risk assessment of chemical pollutants in a petrochemical complex. Iran Occupational Health Journal. 2012;9(3):11-21.
MIR MOHAMMADI ST, HAKIMI E, OMAR K, MOHAMADIAN M, KAMEL K. EVALUATION OF CONCENTRATION METHYLENE DIPHENYL DIISOCYANATE (MDI) IN THE POLYURETHANE INDUSTRIES OF IRAN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES. 2008;18(63):-.
Sepai O, Henschler D, Sabbioni G. Albumin adducts, hemoglobin adducts and urinary metabolites in workers exposed to 4, 4′-methylenediphenyl diisocyanate. Carcinogenesis. 1995;16(10):2583-7.
Safety O, Administration H. Code of Federal Regulations. 29 CFR 1910.95. US Government Printing Office, Office of the Federal Register, OSHA, Washington, DC. 1992.
Alert N. Preventing asthma and death from diisocyanate exposure. DHHS (NIOSH) Publication. 1996(96-111).
PUSCASU S. DÉVELOPPEMENT D'UN NOUVEAU DISPOSITIF D'ÉCHANTILLONNAGE AFIN DE PRÉLEVER DE FAÇON EFFICACE ET CONVIVIALE LES AÉROSOLS DE MÉTHYLÈNE DIPHÉNYLE. 2015.
Montreuil S, Lippel K. Telework and occupational health: a Quebec empirical study and regulatory implications. Safety Science. 2003;41(4):339-58.
Hygienists ACoGI, editor Threshold limit values for chemical substances and physical agents and biological exposure indices1995: American Conference of Governmental Industrial Hygienists.
Carino M, Aliani M, Licitra C, Sarno N, Ioli F. Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject. Respiration. 1997;64(1):111-3.
FIGHTING F, CONTACT AA, DOCTOR IACCA. METHYLENE BISPHENYL ISOCYANATE ICSC: 0298.
AGHANASAB M, NIKPEY A, MOHAMMADI FARD A, KOHNAVARD B, SOLTANI GERDFARAMARZI R. EVALUATION OF EXPOSURE METHYL DIISOCYANATE AND REVIEW OF THE RESPIRATORY CAPACITY OF THE WORKERS EMPLOYED IN THE FOAM MANUFACTURING INDUSTRY. OCCUPATIONAL MEDICINE. 2016;7(4):-.
MORTASAVI SB, JABARI GHARAHBAGH M, KHAVANIN A, SOLIMANIAN A. EVALUATION OF 4,4-METHYLENE DIPHENYL DIISOCYANATE EFFECTS ON FOAM PRODUCING WORKERS OF CAR MANUFACTURE. THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES. 2005;-(34):-.
Cartier A, Grammer L, Malo J-L, Lagier F, Ghezzo H, Harris K, et al. Specific serum antibodies against isocyanates: association with occupational asthma. Journal of Allergy and Clinical Immunology. 1989;84(4):507-14.
Desmodur N. Hexamethylene Diisocyanate Based Polyisocyanates: Health and Safety Information (brochure). Bayer Corporation, Pittsburgh, PA (December 1999). 1999.
Vandenplas O, Cartier A, Lesage J, Perrault G, Grammer LC, Malo J-L. Occupational asthma caused by a polymer but not the monomer of toluene diisocyanate (TDI). Journal of Allergy and Clinical Immunology. 1992;89(6):1183-8.
Vandenplas O, Cartier A, Lesage J, Cloutier Y, Perreault G, Grammer LC, et al. Prepolymers of hexamethylene diisocyanate as a cause of occupational asthma. Journal of Allergy and Clinical Immunology. 1993;91(4):850-61.
Baur X, Marek W, Ammon J, Czuppon A, Marczynski B, Raulf-Heimsoth M, et al. Respiratory and other hazards of isocyanates. International archives of occupational and environmental health. 1994;66(3):141-52.
Mortasavi S, JABARI GM, ASILIAN MH, Khavanin A, Solimanian A. Evaluation of 4, 4-methylene diphenyl diisocyanate effects on foam producing workers of car manufacture. 2005.
Bolognesi C, Baur X, Marczynski B, Norppa H, Sepai O, Sabbioni G. Carcinogenic risk of toluene diisocyanate and 4, 4′-methylenediphenyl diisocyanate: epidemiological and experimental evidence. Critical reviews in toxicology. 2001;31(6):737-72.
Allport DC, Gilbert DS, Outterside S. MDI and TDI: safety, health and the environment: a source book and practical guide: John Wiley & Sons; 2003.
Herber RF, Duffus JH, Christensen JM, Olsen E, Park MV. Risk assessment for occupational exposure to chemicals. A review of current methodology (IUPAC Technical Report). Pure and Applied Chemistry. 2001;73(6):993-1031.
Yari S, Fallah AA, Varmazyar S. Assessment of semi-quantitative health risks of exposure to harmful chemical agents in the context of carcinogenesis in the latex glove manufacturing industry. Asian Pacific journal of cancer prevention: APJCP. 2015;17(205):11.
Money C, Margary S. Improved use of workplace exposure data in the regulatory risk assessment of chemicals within Europe. Annals of Occupational Hygiene. 2002;46(3):279-85.
Nourmohammadi M, Asadi AF, Jarrahi AM, Yari S. Risk of Mortality Caused by Silicosis and Lung Cancer: a Study on Ceramic Tile Factory Workers. Asian Pacific Journal of Environment and Cancer. 2018;1(2).
Jahangiri M, Parsarad M. Health risk assessment of harmful chemicals: case study in a petrochemical industry. Iran Occupational Health. 2010;7(4):18-24.
Yari S, Asadi AF, Normohammadi M. Occupational and Environmental Cancer. Asian Pacific Journal of Environment and Cancer. 2018;1(1).
Yari S, Asadi AF, Jarrahi AM, Normohammadi M. CARcinogen EXposure: CAREX. Asian Pacific Journal of Environment and Cancer. 2018;1(1).
Normohammadi M, Kakooei H, Omidi L, Yari S, Alimi R. Risk assessment of exposure to silica dust in building demolition sites. Safety and health at work. 2016;7(3):251-5.
Yari S. Assessment of potential risk by the failure mode and effects analysis in an air conditioning equipment manufacturing company. Journal of Safety Promotion and Injury Prevention. 2017;5(2).
PIIRILÄ PIL, Nordman H, KESKINEN HM, Luukkonen R, SALO S-PI, TUOMI TO, et al. Long-term follow-up of hexamethylene diisocyanate-, diphenylmethane diisocyanate-, and toluene diisocyanate-induced asthma. American journal of respiratory and critical care medicine. 2000;162(2):516-22.
Streicher RP, Reh CM, Key-Schwartz R, Schlecht PC, Cassinelli ME. Determination of airborne isocyanate exposure. NIOSH manual of analytical methods. 1998:115-40.
Sennbro CJ, Lindh CH, Oestin A, Welinder H, JÖNSSON BA, Tinnerberg H. A survey of airborne isocyanate exposure in 13 Swedish polyurethane industries. Annals of Occupational Hygiene. 2004;48(5):405-14.
Blanc PD, Iribarren C, Trupin L, Earnest G, Katz PP, Balmes J, et al. Occupational exposures and the risk of COPD: dusty trades revisited. Thorax. 2009;64(1):6-12.
Boggia B, Farinaro E, Grieco L, Lucariello A, Carbone U. Burden of smoking and occupational exposure on etiology of chronic obstructive pulmonary disease in workers of Southern Italy. Journal of occupational and environmental medicine. 2008;50(3):366-70.
Wanger J, Irvin CG. Office spirometry: equipment selection and training of staff in the private practice setting. Journal of Asthma. 1997;34(2):93-104.
Saeidabadi H, Nikpey A. Respiratory exposure with acrylonitrile butadiene styrene particle in appliance company workers. J Qazvin Univ Med Sci. 2018;21(1):31-41.
Tsiligianni I, Kocks J, Tzanakis N, Siafakas N, van der Molen T. Factors that influence disease-specific quality of life or health status in patients with COPD: a review and meta-analysis of Pearson correlations. Prim Care Respir J. 2011;20(3).
Karkhanis VS, Joshi J. Spirometry in chronic obstructive lung disease (COPD). J Assoc Physicians India. 2012;2(60):22-6.
Hyatt RE, Scanlon PD, Nakamura M. Interpretation of pulmonary function tests: Lippincott Williams & Wilkins; 2014.
Balmes J, Scannell C. Occupational lung disease. IN: Ladou J. Occupational & Environmental Medicine.4:310-33.
Skarping G, Renman L, Smith B. Trace analysis of amines and isocyanates using glass capillary gas chromatography and selective detection: I. Determination of aromatic amines as perfluoro fatty acid amides using electron-capture detection. Journal of Chromatography A. 1983;267:315-27.
Occupational Exposure limit(OEL). 2016(4):14-5.
Lin F, Parthasarathy S, Taylor SJ, Pucci D, Hendrix RW, Makhsous M. Effect of different sitting postures on lung capacity, expiratory flow, and lumbar lordosis. Archives of physical medicine and rehabilitation. 2006;87(4):504-9.
Briscoe W. Lung volumes. Handbook of physiology. 1965;2:1363-5.
Yang T, Peat J, Keena V, Donnelly P, Unger W, Woolcock A. A review of the racial differences in the lung function of normal Caucasian, Chinese and Indian subjects. European Respiratory Journal. 1991;4(7):872-80.




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