CARcinogen EXposure: CAREX
DOI:
https://doi.org/10.31557/apjec.2018.1.1.19-25Keywords:
CAREX، Carcinogen Exposure, Occupational Cancer، Environmental Cancer, Cancer PreventionAbstract
Cancer is the second common cause of death worldwide and a significant ratio of all cancers is related to occupational and living environments. On the other side, cancer prevalence could be controlled and prevented via policies to improve occupational and living environments. However, a main challenge in prevention of occupational cancer is the lack of knowledge about the exposure rate and number of exposed persons. CAREX database, which is established by the program of Europe against cancer, provides information for the number of exposed persons based on country, carcinogen, and type of industry. CAREX is established in early years of 1990 decade by Finland Institute of Health (FIOH) in cooperation with IARC and European experts, as a tool for estimation of the burden due to occupational cancer in Europe, and shortly thereafter is expanded for use in almost 15 countries in European Union by 55 industrial groups. Several other countries have used CAREX for their countries and have provided some main progressions for the performance model. CAREX project in Canada was modeled in 2007, in an effort to develop a Canadian specific and advanced tool for assessing exposure to carcinogenic agents based on EU CAREX. In this model, not only occupational exposure, but also environmental exposure has been considered. Estimation of exposure with CAREX helps to inform primary prevention activities and to improve global occupational cancer, and its strength points are systematic nature, good coverage and ease of use, and can be used in other countries of the world.
References
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International journal of cancer. 2010;127(12):2893-917.
Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, et al. The global burden of cancer 2013. JAMA oncology. 2015;1(4):505-27.
Espina C, Porta M, Schüz J, Aguado IH, Percival RV, Dora C, et al. Environmental and occupational interventions for primary prevention of cancer: a cross-sectorial policy framework. Environmental health perspectives. 2013;121(4):420.
Peters CE, Calvin BG, Hall AL, Davies HW, Demers PA. CAREX Canada: an enhanced model for assessing occupational carcinogen exposure. Occup Environ Med. 2014:oemed-2014-102286.
Normohammadi M, Kakooei H, Omidi L, Yari S, Alimi R. Risk assessment of exposure to silica dust in building demolition sites. Safety and health at work. 2016;7(3):251-5.
Lynge E, Anttila A, Hemminki K. Organic solvents and cancer. Cancer Causes & Control. 1997;8(3):406-19.
Yari S. Inherent safety design in compose of urban gas station. Safety Promotion and Injury Prevention. 2015;3(2):135-40.
WHO J. Global health risks: mortality and burden of disease attributabbl to selected major risk. Geneva: WHO; 2009.
Prüss-Üstün A, Corvalán C. How much disease burden can be prevented by environmental interventions? Epidemiology. 2007;18(1):167-78.
Setton E, Hystad P, Poplawski K, Cheasley R, Cervantes-Larios A, Keller CP, et al. Risk-based indicators of Canadians’ exposures to environmental carcinogens. Environmental Health. 2013;12(1):15.
IARC. AGENTS CLASSIFIED BY THE IARC MONOGRAPHS, VOLUMES 1–122 2018 [cited 1-122]. Available from: https://monographs.iarc.fr/agents-classified-by-the-iarc/.
Program TNT. Tenth Edition of the Report on Carcinogens.
Health NIfOSa. Occupational Cancer. Available from: http://www.cdc.gov/niosh/topics/cancer/.
Release IP. IARC CLASSIFIES FORMALDEHYDE AS CARCINOGENIC TO HUMANS 2004 [153]. Available from: http://www.iarc.fr/pageroot/PRERELEASES/pr153a.html.
Prüss-Üstün A, Corvalán C. Preventing disease through healthy environments. Towards an estimate of the environmental burden of disease Geneva: World Health Organization. 2006.
Doyle Y, Furey A, Flowers J. Sick individuals and sick populations: 20 years later. Journal of Epidemiology & Community Health. 2006;60(5):396-8.
Asaria P, Chisholm D, Mathers C, Ezzati M, Beaglehole R. Chronic disease prevention: health effects and financial costs of strategies to reduce salt intake and control tobacco use. The Lancet. 2007;370(9604):2044-53.
Tomatis L. Cancer: causes occurence and control. IARC scientific publications. 1990.
Clapp RW, Jacobs MM, Loechler EL. Environmental and occupational causes of cancer: new evidence 2005-2007. Reviews on environmental health. 2008;23(1):1-38.
Kauppinen T, Toikkanen J, Pedersen D, Young R, Ahrens W, Boffetta P, et al. Occupational exposure to carcinogens in the European Union. Occupational and environmental medicine. 2000;57(1):10-8.
Wordsworth A. Prevention of Occupational and Environmental Cancers in Canada. National Committee on Environmental and Occupational Exposures. 2006:107.
Yari S, Fallah AA, Varmazyar S. Assessment of semi-quantitative health risks of exposure to harmful chemical agents in the context of carcinogenesis in the latex glove manufacturing industry. Asian Pacific journal of cancer prevention: APJCP. 2015;17:S3.
Yari S. Assessment of potential risk by the failure mode and effects analysis in an air conditioning equipment manufacturing company. Safety Promotion and Injury Prevention. 2017;5(2):89-96.
Danaei G, Vander Hoorn S, Lopez AD, Murray CJ, Ezzati M, group CRAc. Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. The Lancet. 2005;366(9499):1784-93.
Ashmore J, Krewski D, Zielinski J, Jiang H, Semenciw R, Band P. First analysis of mortality and occupational radiation exposure based on the National Dose Registry of Canada. American journal of epidemiology. 1998;148(6):564-74.
Kauppinen T. Finnish occupational exposure databases. Applied occupational and environmental hygiene. 2001;16(2):154-8.
Kraut A. Estimates of the extent of morbidity and mortality due to occupational diseases in Canada. American journal of industrial medicine. 1994;25(2):267-78.
carexcanada. What is CAREX? 2018. Available from: https://www.carexcanada.ca/en/aboutus/.
Rushton L, Brown T, Cherrie L, Fortunato L, Van Tongeren M, Hutchings S. How much does benzene contribute to the overall burden of cancer due to occupation? 2010.
Mirabelli D. Estimated number of workers exposed to carcinogens in Italy, within the context of the European study CAREX. Epidemiologia e prevenzione. 1999;23(4):346-59.
Heikkilä P, Kauppinen T. Occupational exposure to carcinogens in Finland. American journal of industrial medicine. 1992;21(4):467-80.
Partanen T, Chaves J, Wesseling C, Chaverri F, Monge P, Ruepert C, et al. Workplace carcinogen and pesticide exposures in Costa Rica. International journal of occupational and environmental health. 2003;9(2):104-11.
Ezzati M, Lopez AD, Rodgers A, Vander Hoorn S, Murray CJ, Group CRAC. Selected major risk factors and global and regional burden of disease. The Lancet. 2002;360(9343):1347-60.
Rushton L, Bagga S, Bevan R, Brown T, Cherrie J, Holmes P, et al. Occupation and cancer in Britain. British Journal of Cancer. 2010;102(9):1428.
Peters C, Pahwa M, Demers P. 0284 Carex: an occupational exposure surveillance system overview. BMJ Publishing Group Ltd; 2017.
Angeles J. Estimating the burden of occupational bladder cancer in Ontario using the CAREX Canada database 2008.
Leem J-H, Kim H-C, Ryu J-S, Won JU, Moon JD, Kim Y-C, et al. Occupational lung cancer surveillance in South Korea, 2006-2009. Safety and health at work. 2010;1(2):134-9.
Armstrong BG, Gibbs G. Exposure-response relationship between lung cancer and polycyclic aromatic hydrocarbons (PAHs): estimates from a large aluminium smelter cohort. Occupational and environmental medicine. 2009.
Pajarskiene B, Kauppinen T. Occupational exposure to carcinogens in Lithuania in 1997. Helsinki: Finnish Institute of Occupational Health. 2000.
Mirabelli D. Stima del numero di lavoratori esposti a cancerogeni in Italia, nel contesto dello studio europeo CAREX. Epid Prev. 1999;23(4):346-59.
Ladou J, Teitelbaum DT, Egilman DS, Frank AL, Kramer SN, Huff J. American College of Occupational and Environmental Medicine (ACOEM): a professional association in service to industry. International journal of occupational and environmental health. 2007;13(4):404-26.
Mirabelli D, Kauppinen T. Occupational exposures to carcinogens in Italy: an update of CAREX database. International journal of occupational and environmental health. 2005;11(1):53-63.
Guzman JR, Demers PA, Pahwa M, Peters CE, Calvin BG. S10-3 Establishing national carcinogen exposure (CAREX) programs in latin america and the caribbean: achievements and future directions. BMJ Publishing Group Ltd; 2016.
Lippel K, Eakin J, Holness L, Howse D. MONDAY, OCTOBER 20, 2014.
health fioo. International Information System on Occupational Exposure to Carcinogens 2018. Available from: https://www.ttl.fi/en/carex/.
Demers PA, Peters CE, Davies HW, MCalvin BG, Hall AL, Kim J, et al. S10-2 Carex canada: innovations and applications. BMJ Publishing Group Ltd; 2016.
Takala J. Eliminating occupational cancer in Europe and globally. 2015.
Kauppinen T, Uuksulainen S, Saalo A, Mäkinen I, Pukkala E. Use of the Finnish Information System on Occupational Exposure (FINJEM) in epidemiologic, surveillance, and other applications. Annals of occupational hygiene. 2014;58(3):380-96.
Lißner TL, Kooperationsstelle Hamburg I, Kuhl K. Europe Direct-palvelu auttaa sinua löytämään vastaukset EU: hun liittyviin kysymyksiisi. 2014.
Kauppinen T, Toikkanen J, Pukkala E. From cross‐tabulations to multipurpose exposure information systems: a new job‐exposure matrix. American journal of industrial medicine. 1998;33(4):409-17.
Driscoll T, Steenland K, Nelson DI, Prüss-Üstün A, Campbell-Lendrum DH, Corvalán CF, et al. Occupational carcinogens: assessing the environmental burden of disease at national and local levels. 2004.
Demers PA, Nicol A-M. Development of a Provincial Exposure Database for Manitoba. 2014.
Peters CE, Palmer AL, Telfer J, Calvin BG, Hall AL, Davies HW, et al. Priority Setting for Occupational Cancer Prevention. Safety and health at work. 2018;9(2):133-9.
Kim J, Labrèche F, Song C, Peters CE, Davies HW, Lavoué J, et al. O39-3 Accounting for exposure to multiple carcinogens in occupational cancer burden estimation. BMJ Publishing Group Ltd; 2016.
Kromhout H. S10-4 Linking carex with exposure measurement databases. BMJ Publishing Group Ltd; 2016.
Tompa E, Kalcevich C, McLeod C, Lebeau M, Song C, McLeod K, et al. The economic burden of lung cancer and mesothelioma due to occupational and para-occupational asbestos exposure. Occup Environ Med. 2017:oemed-2016-104173.
Pasetto R, Terracini B, Marsili D, Comba P. Occupational burden of asbestos-related cancer in Argentina, Brazil, Colombia, and Mexico. Annals of global health. 2014;80(4):263-8.
Hohenadel K, Pichora E, Marrett L, Bukvic D, Brown J, Harris S, et al. ARCHIVED-Chronic Diseases and Injuries in Canada.
Hohenadel K, Pichora E, Marrett L, Bukvic D, Brown J, Harris S, et al. Priority issues in occupational cancer research: Ontario stakeholder perspectives. advocate. 2011;21:11.9.
Johnson KC. National Enhanced Cancer Surveillance System: a federal-provincial collaboration to examine environmental cancer risks [Status report]. Chronic Diseases and Injuries in Canada. 2000;21(1):34.
Hall AL, Peters CE, Demers PA, Davies HW. Exposed! Or not? The diminishing record of workplace exposure in Canada. Can J Public Health. 2014;105(3):214-7.
Mullan N, Ferguson C, Paech D, Australia W. Environmental Health Surveillance. 2008.
Kauppinen T, Pajarskiene B, Podniece Z, Rjazanov V, Smerhovsky Z, Veidebaum T, et al. Occupational exposure to carcinogens in Estonia, Latvia, Lithuania and the Czech Republic in 1997. Scandinavian journal of work, environment & health. 2001:343-5.
Demers PA, Peters C, Pahwa M, MacLeod J, Kim J. 0452 Uses of carex systems for individual countries and international contexts. BMJ Publishing Group Ltd; 2017.
González CA, Agudo A. Occupational cancer in Spain. Environmental Health Perspectives. 1999;107(Suppl 2):273.
Blair A, Marrett L, Freeman LB, editors. Occupational cancer in developed countries. Environmental Health; 2011: BioMed Central.
Martín-Bustamante M, Molinero-Ruiz E. S10-1 Occupational exposure to carcinogens in catalonia: carex-cat. knowledge into action. BMJ Publishing Group Ltd; 2016.
Julià M, Vives A, Tarafa G, Benach J. S09-4 The precarization of the spanish labour market and its impact on mental health. BMJ Publishing Group Ltd; 2016.
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